Streptomycin in Tuberculosis

[Streptomycin in the treatment of tuberculosis in children; streptomycin in the treatment of miliary tuberculosis].

The potent bactericidal activity of streptomycin in the guinea pig model of tuberculosis ceases due to the presence of persisters.

OBJECTIVES The biphasic kill curve of isoniazid against Mycobacterium tuberculosis in guinea pigs is due to the presence of persisters rather than selection of isoniazid-resistant mutants. To determine whether this phenomenon is common to other bactericidal drugs, we studied the activity of streptomycin and its ability to select for streptomycin-resistant mutants in the guinea pig model of tube...

CHILDHOOD RESPIRATORY TUBERCULOSIS IN IRAN

To estimate the bacterio-epidemiological situation of childhood respiratory tuberculosis in Iran, 2185 symptomatic patients of 0-14 years old were studied. Among 110 bacteriologically confirmed cases, 60% were less than five years old and the number of females was slightly more than males. In 21 % of patients, the Mantoux test was negative. None of the miliary cases had a history of BCG va...

Optimized preparation and evaluation of 99mTc-Streptomycin

Introduction: The endemic occurrence of new strains of tuberculosis around the globe has initiated new research on developing diagnostic radiopharmaceutical based on antibiotics. Methods:Tc-99m labeled streptomycin was prepared using freshly milked 99mTcO4- and various concentrations of streptomycin, stannous chloride at various temperatures in high yield radio...

A STUDY OF MYCOBACTERIUM TUBERCULOSIS DRUG RESISTANCE IN PULMONARY TUBERCULOSIS

Tuberculosis remains a major public health problem in both developing and developed countries. Drug-resistant tuberculosis is an increasing health problem and serious challenge to tuberculosis (TB) control programs. Information about the susceptibility pattern of Mycobacterium tuberculosis isolates against anti-tuberculosis drugs is an important aspect to TB control. The objectives of the s...

Effect of para-aminosalicylic acid (PAS) alone and in association with streptomycin on experimental ocular tuberculosis.

THE therapeutic effects of streptomycin and of para-aminosalicylic acid (PAS) in the control of many forms of experimentally induced tuberculosis and in' the treatment of clinical tuberculosis are now well known. Although streptomycin is the most powerful antituberculosis drug which has so far been fully evaluated, evidence is accumulating that a combination of streptomycin and PAS is even more...